NLRP3 Attenuates Intraocular Inflammation by Inhibiting AIM2-Mediated Pyroptosis Through the Phosphorylated Salt-Inducible Kinase 1/Sterol Regulatory Element Binding Transcription Factor 1 Pathway.

Jiayu MengNa LiXianyang LiuShengjun QiaoQian ZhouJun TanTing ZhangZhifang DongXiaopeng QiAize KijlstraLiming MaoPeizeng Yang Shengping Hou

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Our data demonstrate that NLRP3 inhibits AIM2 inflammasome-mediated EAU by regulating the p-SIK1/SREBF1 pathway, highlighting the therapeutic potential of targeting Nlrp3.

Keyphrases

transcription factor
nlrp inflammasome
dna binding
oxidative stress
signaling pathway
electronic health record
machine learning
protein kinase
drug delivery
deep learning
data analysis