Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics.

Ryohei YoshitakeHitomi MoriDesiree HaXiwei WuJinhui WangXiaoqiang WangKohei SaekiGregory ChangHyun Jeong ShimYin ChanShiuan Chen

Published in: Clinical and translational medicine (2024)

Our study identified the gene signature in our 'proliferative' compartment as an important determinant of luminal cancer subtypes. This 'proliferative' cell population is a causative feature of luminal B breast cancer, contributing toward its aggressive behaviours.

Keyphrases

single cell
rna seq
high throughput
papillary thyroid
genome wide
squamous cell
deep learning
cell therapy
stem cells
copy number
dna methylation
neural network