Occurrence of Retinal Ganglion Cell Loss via Autophagy and Apoptotic Pathways in an Autoimmune Glaucoma Model.
Sabrina ReinehrVerena BuschhornAna M Mueller-BuehlTobias GoldmannFranz H GrusUwe WolfrumH Burkhard DickStephanie Christine JoachimPublished in: Current eye research (2020)
Due to the novel results from this study, we conclude that IgG antibodies are involved in RGC loss in this model leading to apoptotic and autophagic cell loss. These results could help to develop new therapy strategies for glaucoma patients.
Keyphrases
- cell death
- single cell
- cell therapy
- end stage renal disease
- ejection fraction
- newly diagnosed
- risk assessment
- multiple sclerosis
- chronic kidney disease
- signaling pathway
- stem cells
- peritoneal dialysis
- prognostic factors
- anti inflammatory
- optic nerve
- endoplasmic reticulum stress
- patient reported outcomes
- drug induced
- smoking cessation
- replacement therapy