A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation.

Zhen-Xing LiangHua-Shan LiuLi XiongXin YangFeng-Wei WangZi-Wei ZengXiao-Wen HeXian-Rui WuPing Lan

Published in: Molecular cancer (2021)

circPLCE1 presents an epigenetic mechanism which disrupts NF-κB nuclear translocation and serves as a novel and promising therapeutic target and prognostic marker.

Keyphrases

signaling pathway
lps induced
pi k akt
nuclear factor
oxidative stress
dna methylation
gene expression
inflammatory response
transcription factor
small molecule
toll like receptor
immune response