Inhibition of mPGES-2 ameliorates NASH by activating NR1D1 via heme.

Dandan ZhongJie CaiCheng HuJingshuo ChenRumeng ZhangChenyu FanShanshan LiHongxing ZhangZhou XuZhanjun JiaDong GuoYing Sun

Published in: Hepatology (Baltimore, Md.) (2022)

Our study indicates the pathogenic role of mPGES-2 and outlines the mechanism in mediating NAFLD, thereby highlighting the therapeutic potential of mPGES-2 inhibition in liver steatosis and steatohepatitis.

Keyphrases

insulin resistance
signaling pathway
high fat diet
mouse model
type diabetes
metabolic syndrome