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DOSAGE study: protocol for a phase III non-inferiority randomised trial investigating dose-reduced chemotherapy for advanced colorectal cancer in older patients.

Joosje C BaltussenFrederiek van den BosMarije SlingerlandTrishika R R BindaGerrit-Jan LiefersWilbert B van den HoutMarta FioccoArjan J VerschoorMarissa Cloos-van BalenCynthia HolterhuesDanny HoutsmaAnouk JochemsLeontine E A M M SpieringsLeti van Bodegom-VosSimon Pieter MooijaartHans GelderblomFrank M SpeetjensNienke A de GlasJohanneke E A Portielje
Published in: BMJ open (2024)
NCT06275958.
Keyphrases
  • phase iii
  • open label
  • clinical trial
  • phase ii
  • study protocol
  • locally advanced
  • double blind
  • placebo controlled
  • squamous cell carcinoma
  • rectal cancer
  • chemotherapy induced
  • radiation therapy