Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis.

Zoë Y G J van LieropSamantha NoteboomMartijn D SteenwijkMaureen van Dam Alyssa A TooropZoé LE van KempenBastiaan MoraalFrederik BarkhofBernard Mj UitdehaagMenno Michiel SchoonheimCharlotte E TeunissenJoep Killestein

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2022)

Year 1 (but not baseline) sNfL level was predictive for long-term brain atrophy in patients treated with natalizumab. sCNTN1 level did not show a clear predictive value.

Keyphrases

multiple sclerosis
white matter
resting state
functional connectivity
cerebral ischemia
cerebrospinal fluid