CDK4/6 Inhibitors: What Is the Best Cocktail?
Marcos MalumbresPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
CDK4/6 inhibitors have shown great potential in the new armamentarium against cancer. However, their effect as single agents is limited, and the hopes are on new combinatory strategies. Recent data suggest that inhibiting mTOR may significantly cooperate with cell-cycle arrest in a variety of cancers.See related article by Song et al., p. 403.
Keyphrases
- cell cycle arrest
- cell cycle
- cell death
- pi k akt
- papillary thyroid
- signaling pathway
- cell proliferation
- electronic health record
- squamous cell
- childhood cancer
- big data
- machine learning
- risk assessment
- human health
- squamous cell carcinoma
- lymph node metastasis
- young adults
- deep learning
- climate change
- artificial intelligence