Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck.
Jong Woo LeeJanaki ParameswaranTeresa Sandoval-SchaeferKyung Jin EohDong-Hua YangFang ZhuRanee MehraRoshan SharmaStephen G GaffneyElizabeth B PerryJeffrey P TownsendIlya G SerebriiskiiErica A GolemisNatalia IssaevaWendell G YarbroughJa Seok KooBarbara BurtnessPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Combinatorial treatment with adavosertib and alisertib leads to synergistic antitumor effects in in vitro and in vivo HNSCC models. These findings suggest a novel rational combination, providing a promising therapeutic avenue for TP53-mutated cancers.