IgE-mediated chlorhexidine allergy-Cross-reactivity with other biguanide disinfectants.

Nicole Mueller-WirthAntonia BuenterLukas JoergDidier G EboMartin GlatzSuran L FernandoDavid SpoerlArthur HelblingOliver HausmannNisha GuptaWerner J Pichler

Published in: Allergy (2020)

The IgE response to CHX seems polyclonal. The chloroguanide ending of CHX is the main epitope for the IgE and is suitable as screening assay to detect CHX reactivity. IgE-reactivities with the biguanide or hexamethylene components of other disinfectants (ALX, PHMB) can be detected by SPT, PHMB ImmunoCAP, and ALX-BAT in 15%-33% of CHX-allergic patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
high throughput
peritoneal dialysis
atopic dermatitis
patient reported outcomes
allergic rhinitis