Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury.

Sanjin HosicWill LakeEric StasRyan KoppesDavid T BreaultShashi K MurthyAbigail N Koppes

Published in: Cellular and molecular bioengineering (2020)

A primary model of intestinal inflammation was evaluated, demonstrating nAChR or mAChR activation does not have the same protective effects compared to immortalized epithelium. Inclusion of other native stromal support cells are underway.

Keyphrases

induced apoptosis
endothelial cells
oxidative stress
high glucose
rheumatoid arthritis
cell cycle arrest
bone marrow
diabetic rats
induced pluripotent stem cells
cell death
endoplasmic reticulum stress
signaling pathway