Genome-wide association study across pediatric central nervous system tumors implicates shared predisposition and points to 1q25.2 (PAPPA2) and 11p12 (LRRC4C) as novel candidate susceptibility loci.

Jon Foss-SkiftesvikChristian Munch HagenRené MathiasenDea AdamsenMarie Bækvad-HansenAnders D BørglumMerete NordentoftThomas WergeMichael ChristiansenKjeld SchmiegelowMarianne JuhlerPreben Bo MortensenDavid Michael HougaardJonas Bybjerg-Grauholm

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)

This GWAS indicates shared susceptibility attributable to common variants across pediatric CNS tumor types. Variations in genetic loci with roles in CNS development appear to be involved, possibly via altered IGF-I related pathways.

Keyphrases

genome wide association study
copy number
blood brain barrier
genome wide
cerebrospinal fluid
binding protein
pi k akt
cell proliferation
signaling pathway
genome wide association