A novel 1,8-Naphthalimide-based fluorescent chemosensor for the detection of HSA in living cells.

Human serum albumin (HSA) is an essential protein for maintaining human health. Accurate detection and quantification of HSA is of great significance for disease diagnosis and biochemical research. Herein, a new HSA fluorescence probe BNPE based on 1, 8-naphthalimide fluorophore was designed and synthesized. The probe could recognize HSA through TICT mechanism, effectively avoid the interference of most substances, and realize HSA fluorescence imaging in living cells.