First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G.

François AnnaElodie Bole-RichardJoel LeMaoultMarie EscandeMartin LecomteJean-Marie CertouxPhilippe SouqueFrancine GarnacheOlivier AdotéviPierre Langlade-DemoyenMaria LoustauJulien Caumartin

Published in: Journal for immunotherapy of cancer (2021)

We report for the first time that HLA-G, which is both a TSA and an ICP, constitutes a valid target for CAR-T cell therapy to specifically target and eliminate both tumor cells and HLA-G+ suppressive cells.

Keyphrases

cell therapy
induced apoptosis
stem cells
mesenchymal stem cells
cell cycle arrest
signaling pathway
amino acid