CXCL12/CXCR4 axis gene variants contribute to an increased vulnerability to HPV infection and cervical oncogenesis.

Nádia Calvo Martins Okuyama Fernando Cezar-Dos-Santos Kleber Paiva Trugilo Aline Esposito Roberta Losi Guembarovski José d'Oliveira Couto-Filho Maria Angelica Ehara Watanabe Karen Brajão de Oliveira

Published in: Journal of cancer research and clinical oncology (2022)

This is the first study demonstrating that the interaction of CXCL12 and CXCR4 variants contributes to the increased susceptibility of HPV infection, squamous intraepithelial lesions and cervical cancer development.

Keyphrases

high grade
copy number
low grade
climate change
genome wide
dna methylation
cervical cancer screening