Objective assessment of the effects of opicapone in Parkinson's disease through kinematic analysis.
Alfredo BerardelliAndrea GuerraDonato ColellaDaniele BirreciDavide CostaAntonio CannavacciuoloLuca AngeliniGiulia PaparellaAngelo AntoniniAlfredo BerardelliGiovanni FabbriniPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
This study is the first objective assessment of the effects of adding OPC to L-DOPA on bradykinesia in patients with PD and motor fluctuations. OPC, in addition to the standard dopaminergic therapy, leads to significant improvements in bradykinesia during clinically relevant periods associated with peripheral L-DOPA dynamics, i.e., the OFF state in the morning, delayed-ON, and wearing-OFF periods.