Transient abnormal myelopoiesis in Down syndrome: Experience of long term follow up from a single tertiary center in Thailand.
Thirachit ChotsampancharoenShevachut ChavananonPornpun SripornsawanNatsaruth SongthaweeEdward B McNeilPublished in: Pediatric hematology and oncology (2022)
Transient abnormal myelopoiesis (TAM) is a unique disease occurring in Down syndrome (DS) infants from which most patients have spontaneous remission. This study aimed to evaluate the incidence and outcomes of TAM in a tertiary center in Thailand. We reviewed the records of 997 DS patients diagnosed between June 1993 and October 2019. From the 997 DS patients, 32 had been diagnosed with TAM. The incidence of TAM was 3.2% and an overall survival rate of 87.5%. A total of 2/28 who survived (7.1%) subsequently developed AML-DS at the ages of 2.1 and 4.5 years, respectively. The risk factors related with death included maternal multiparity, sepsis, skin bleeding, subcutaneous nodules, high WBC count, low hemoglobin, and elevated AST level.Abbreviations.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- risk factors
- prognostic factors
- rheumatoid arthritis
- metabolic syndrome
- body mass index
- intensive care unit
- insulin resistance
- acute kidney injury
- atrial fibrillation
- pregnant women
- adipose tissue
- acute lymphoblastic leukemia
- wound healing
- weight gain
- cerebral ischemia
- red blood cell