Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction.

Youming ZhangZichun CaiYunli ShenQizheng LuWei GaoXin ZhongKang YaoJie YuanHaibo Liu

Published in: Journal of nanobiotechnology (2021)

Our novel delivery method provides an innovative tool for enhancing the therapeutic effects of DEXs after MI. Further analysis revealed that DEXs exert effect by activating Treg cells and by modifying the polarization of macrophages.

Keyphrases

induced apoptosis
dendritic cells
cell cycle arrest
stem cells
heart failure
mesenchymal stem cells
endoplasmic reticulum stress
oxidative stress
cell death
regulatory t cells
single cell
bone marrow
atrial fibrillation
tissue engineering