Pulsatile corticoid therapy reduces interictal epileptic activity burden in children with genetic drug-resistant epilepsy.
Katharina SchillerJohn ThomasTamir AvigdorDaniel MansillaAline KortasGabriele UnterholznerMarkus RauchenzaunerBirgit FrauscherPublished in: Epilepsia open (2024)
In this study, children with a form of epilepsy, which is resistant against antiseizure medication, received a systematic treatment with corticosteroids over multiple cycles in the hospital. It was found that not only the epileptic activity was reduced but also the sleep of the patients was improved after the treatment. These findings could provide the basis for extending the use of corticosteroids in children with epilepsy.
Keyphrases
- drug resistant
- young adults
- multidrug resistant
- end stage renal disease
- healthcare
- chronic kidney disease
- ejection fraction
- newly diagnosed
- acinetobacter baumannii
- emergency department
- genome wide
- stem cells
- combination therapy
- physical activity
- dna methylation
- risk factors
- mesenchymal stem cells
- gene expression
- depressive symptoms
- copy number
- replacement therapy
- acute care
- electronic health record