IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head.

Xue-Zhen LiangXiao-Chen LiuSong LiMing-Tao WenYan-Rong ChenDi LuoBo XuNian-Hu LiGang Li

Published in: Journal of orthopaedic surgery and research (2023)

The occurrence of SONFH was associated with a "multi-target" and "multi-pathway" pattern, especially related to immunity, and IRF8 and its noncoding RNA were closely related to the development of SONFH. The CMap, DGIdb and L1000FWD databases could be effectively used in a systematic manner to predict potential drugs for the prevention and treatment of SONFH. However, additional clinical and experimental research is warranted.

Keyphrases

dendritic cells
risk assessment
drug induced
human health
oxidative stress
combination therapy
replacement therapy