Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression.
Jacqueline KiewaSamantha E Meltzer-BrodyJeanette MilgromJerry GuintivanoIan B HickieDavid C WhitemanCatherine M OlsenLucía Colodro-CondeSarah E MedlandNicholas G MartinNaomi R WrayEnda M ByrnePublished in: Depression and anxiety (2022)
PND has a high genetic overlap with MDD, but points of distinction focus on differential expression in ovarian tissue and higher MDD PGS, particularly for women experiencing both antenatal and postpartum PND.