Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1 / adipokines / PPARγ and IGF-1.
Hanan Abdel Moneam A ShamardlNoha Abdellatif IbrahimDina H MerzebanAzza M ElamirRehab M GolamAsmaa M ElsayedPublished in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2023)
Protective effects of the drugs may be through correlations between SIRT-1/adipokines/IGF-1 and PPARγ, improving the cross-talk between insulin resistance, obesity markers, liver dysfunction, and TNF-α. Promising multi-beneficial therapies of resveratrol or dulaglutide in MS are recommended clinically for this purpose. Showing the Experimental Design.
Keyphrases
- insulin resistance
- metabolic syndrome
- oxidative stress
- adipose tissue
- high fat diet induced
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- type diabetes
- ischemia reperfusion injury
- pi k akt
- mass spectrometry
- rheumatoid arthritis
- binding protein
- uric acid
- multiple sclerosis
- ms ms
- growth hormone
- cardiovascular disease
- glycemic control
- signaling pathway
- weight loss