Nonsteroidal anti-inflammatory drugs prevent gastric cancer associated with the use of proton pump inhibitors after Helicobacter pylori eradication.
Junya AraiRyota NiikuraYoku HayakawaHiroki SatoTakuya KawaharaTetsuro HondaKenkei HasataniNaohiro YoshidaTsutomu NishidaTetsuya SumiyoshiShu KiyotokiTakashi IkeyaMasahiro AraiNobumi SuzukiYosuke TsujiAtsuo YamadaKazuhiko KoikePublished in: JGH open : an open access journal of gastroenterology and hepatology (2021)
NSAIDs were associated with a 60% decrease in the gastric cancer incidence in H. pylori-eradicated PPI users, with dose and duration response effects. NSAIDs may be effective for chemoprevention against PPI-related gastric cancer.