Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome.

Published in: Cardiovascular therapeutics (2019)

CYP2C19 and PON1 Q192R variants influence ADP-induced platelet inhibition by thrombelastography (TEG) in ACS patients with clopidogrel. In addition, both LOF CYP2C19 and PON1 192R variants are independent risk factors of HPR, which is measured by the relative platelet inhibition.

Keyphrases

acute coronary syndrome
risk factors
percutaneous coronary intervention
copy number
antiplatelet therapy
high glucose
diabetic rats
oxidative stress
endothelial cells
atrial fibrillation
dna methylation
genome wide