LNCHC directly binds and regulates YBX1 stability to ameliorate metabolic dysfunction-associated steatotic liver disease progression.

Kaikai LuXiaona ChengLei HeMengda LiQian ChenChen QianRong ZhaoLuyun YangFangtong LiuSitong LiuTianyun ZhangLina FengLitao WuXiaodan WuNan XuYa LiJun WangYu HanHaiyang YuanTiemin LiuMing-Hua ZhengShemin LuDongmin Li

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

In summary, our findings unveil a novel LNCHC functionality in regulating YBX1 and PNPLA3 mRNA stability during MASLD development, providing new avenues in MASLD treatment.

Keyphrases

oxidative stress
smoking cessation