Pharmacokinetics of Curcumin Diethyl Disuccinate, a Prodrug of Curcumin, in Wistar Rats.
Kunan BangphumiChuleeporn KittiviriyakulPasarapa TowiwatPornchai RojsitthisakPhisit KhemawootPublished in: European journal of drug metabolism and pharmacokinetics (2018)
Curcumin diethyl disuccinate did not significantly improve the oral bioavailability of curcumin due to first pass metabolism in the gastrointestinal tract. Further studies on reduction of first pass metabolism are required to optimise delivery of curcumin using a prodrug approach.
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