The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma.

Zhiyuan LiuSongtao WangKuo YuKaile ChenLiang ZhaoJiayue ZhangKexiang DaiPeng Zhao

Published in: Journal of translational medicine (2023)

Our study elucidated the role of MAD2L2 in maintaining glioblastoma stemness and promoting malignant behaviors through the regulation of c-MYC, suggesting its potential as a therapeutic target.

Keyphrases

stem cells
epithelial mesenchymal transition
cancer stem cells
signaling pathway