Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.

Qing ZhouYuyan WangZongshi LuBowen WangLi LiMei YouLijuan WangTingbing CaoYu ZhaoQiang LiAidi MouWentao ShuHongbo HeZhigang ZhaoDaoyan LiuZhiming ZhuPeng Gao Zhencheng Yan

Published in: Obesity (Silver Spring, Md.) (2023)

This study emphasizes an important preventive role of SIRT3 in macrophage polarization and implies that SIRT3 is a promising therapeutic target for obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
oxidative stress
ischemia reperfusion injury
type diabetes
high fat diet induced
weight gain
adipose tissue