CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses.

Camilla BoveSilvia ArcangeliLaura FalconeBarbara CamisaRita El KhouryBeatrice GrecoAnna De LuciaAlice BergaminiAttilio BondanzaFabio CiceriChiara BoniniMonica Casucci

Published in: Journal for immunotherapy of cancer (2023)

Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.

Keyphrases

nk cells
induced apoptosis
cell therapy
stem cells
cell cycle arrest
big data
drug delivery
signaling pathway
human health
artificial intelligence