UroMark-a urinary biomarker assay for the detection of bladder cancer.

Andrew FeberPawan DhamiLiqin DongPatricia de WinterWei Shen TanMónica Martínez-FernándezDirk S PaulAntony Hynes-AllenSheida RezaeePratik GurungSimon RodneyAhmed MehmoodFelipe VillacampaFederico de la RosaCharles JamesonKar Keung ChengMaurice P ZeegersRichard T BryanNicholas D JamesJesus M ParamioAlex FreemanStephan BeckJohn D Kelly

Published in: Clinical epigenetics (2017)

Epigenetic urinary biomarkers for detection of BC have the potential to revolutionise the management of this disease. In this proof of concept study, we show the development and utility of a novel high-throughput, next-generation sequencing-based biomarker for the detection of BC-specific epigenetic alterations in urine.

Keyphrases

high throughput
loop mediated isothermal amplification
dna methylation
real time pcr
label free
gene expression
copy number
genome wide
risk assessment
climate change
quantum dots
circulating tumor cells
cell free