Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Evolves from TP53-Mutated Clonal Hematopoiesis.
Ryunosuke SaikiSeishi OgawaPublished in: Blood cancer discovery (2023)
Low-hypodiploid acute lymphoblastic leukemia (LH-ALL) in both children and adults is characterized by biallelic TP53 alterations in virtually all cases. However, in contrast to a common germline origin of the TP53 mutations in pediatric cases, those in adult cases are mostly somatic and are derived from age-related clonal hematopoiesis (ARCH), highlighting the role of TP53-mutant ARCH in the development not only of myeloid leukemogenesis but also of LH-ALL in aged populations. See related article by Kim et al., (4).
Keyphrases
- acute lymphoblastic leukemia
- allogeneic hematopoietic stem cell transplantation
- magnetic resonance
- dendritic cells
- bone marrow
- acute myeloid leukemia
- childhood cancer
- copy number
- dna repair
- gene expression
- magnetic resonance imaging
- aortic dissection
- wild type
- computed tomography
- immune response
- dna damage
- drug induced
- genome wide
- hematopoietic stem cell
- genetic diversity