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Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).

Muhammed Burak DemircanTina M SchnoederPeter C MgbechetaKatrin SchröderFrank-D BöhmerFlorian H Heidel
Published in: Journal of cancer research and clinical oncology (2022)
The role of NOX4 in myeloid malignancies appears highly context-dependent and its inactivation results in either enhancing or inhibitory effects. Therefore, targeting NOX4 in FLT3-ITD positive myeloid malignancies requires additional pre-clinical assessment.
Keyphrases
  • acute myeloid leukemia
  • reactive oxygen species
  • allogeneic hematopoietic stem cell transplantation
  • bone marrow
  • dendritic cells
  • cancer therapy
  • drug delivery