Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).

Muhammed Burak DemircanTina M SchnoederPeter C MgbechetaKatrin SchröderFrank-D BöhmerFlorian H Heidel

Published in: Journal of cancer research and clinical oncology (2022)

The role of NOX4 in myeloid malignancies appears highly context-dependent and its inactivation results in either enhancing or inhibitory effects. Therefore, targeting NOX4 in FLT3-ITD positive myeloid malignancies requires additional pre-clinical assessment.

Keyphrases

acute myeloid leukemia
reactive oxygen species
allogeneic hematopoietic stem cell transplantation
bone marrow
dendritic cells
cancer therapy
drug delivery