Longitudinal changes to quadriceps thickness demonstrate acute sarcopenia following admission to hospital for an exacerbation of chronic respiratory disease.
Hamish Joseph Cameron McAuleyTheresa C Harvey-DunstanMichelle CranerMatthew RichardsonSally J SinghMichael C SteinerNeil J GreeningPublished in: Thorax (2020)
Acute admission to hospital for an exacerbation of chronic respiratory disease (CRD) may impair skeletal muscle mass and function. We measured quadriceps thickness (Qthick), as a surrogate marker of muscle mass, at hospital admission, discharge, 6 weeks and 3 months in 55 patients with CRD. Qthick fell by 8.3% during the period of hospitalisation, which was sustained at 6 weeks, and only partially recovered at 3 months. Sustained loss was most marked in patients readmitted during the follow-up period. Acute reduction in quadriceps muscle mass occurs during hospitalisation, with prolonged and variable recovery, which is prevented with subsequent hospital readmission.
Keyphrases
- respiratory failure
- liver failure
- emergency department
- healthcare
- drug induced
- chronic obstructive pulmonary disease
- acute care
- adverse drug
- end stage renal disease
- chronic kidney disease
- aortic dissection
- optical coherence tomography
- ejection fraction
- newly diagnosed
- skeletal muscle
- prognostic factors
- anterior cruciate ligament reconstruction
- hepatitis b virus