A once-a-month oral contraceptive.
Ameya R KirtaneTiffany HuaAlison M HaywardAmbika BajpayeeAniket WahaneAaron LopesTaylor BenselLihong MaFrank Z StanczykSierra BrooksDeclan GwynneJacob WainerGiovanni TraversoSiddartha M TamangRobert S LangerGiovanni TraversoPublished in: Science translational medicine (2020)
Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.