Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions.

Meng-Na WangHai-Tao YuYa-Qian LiYun ZengShuang YangGuo-Ping YangQi PeiJie Huang

Published in: Drug design, development and therapy (2021)

The test drug and the reference drug were BE and well tolerated in Chinese healthy subjects under both fasting and fed conditions. Food-intake may cause a significant difference in the main PK parameters of the two preparations.

Keyphrases

blood glucose
insulin resistance
adverse drug
type diabetes
emergency department
metabolic syndrome
weight loss