Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases.
Megan K HerbertJudith Stammen-VogelzangsMarcel M VerbeekAnke RietveldIngrid E LundbergHector ChinoyJanine A LambRobert G CooperMark RobertsUmesh A BadrisingJan L De BleeckerPedro M MachadoMichael G HannaLenka PlestilovaJiri VencovskyBaziel G van EngelenGer J M PruijnPublished in: Annals of the rheumatic diseases (2015)
In summary, we found frequent anti-cN-1A autoantibodies in sera from patients with IBM. Heterogeneity in reactivity with the three immunodominant epitopes indicates that serological assays should not be limited to a distinct epitope region. The similar reactivities observed for SjS and SLE demonstrate the need to further investigate whether distinct IBM-specific epitopes exist.