Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.

Xiuchao WangYunzhan LiZekun LiShengchen LinHongwei WangJianwei SunChungen LanLiangliang WuDongxiao SunChongbiao HuangPankaj K SinghNadine Hempel Mohamed Trebak Gina M DeNicolaJihui HaoShengyu Yang

Published in: Cancer research (2022)

Elevated mitochondrial calcium uptake in PDAC promotes metastasis but exposes cystine addiction and ferroptosis sensitivity that could be targeted to improve pancreatic cancer treatment.

Keyphrases

oxidative stress
cell death
cancer therapy
drug delivery