A novel population of memory-activated natural killer cells associated with low parasitaemia in Plasmodium falciparum-exposed sickle-cell trait children.
Claire LoiseauOgobara K DoumboBoubacar TraoreJamie L BradyCarla ProiettiKarina P de SousaPeter Dobbs CromptonDenise L DoolanPublished in: Clinical & translational immunology (2020)
Our data suggest that this novel memory-activated NK cell subset may contribute to an accelerated and enhanced IFN-γ-mediated immune response and to control of parasite density in individuals with the sickle-cell trait. This distinct cellular immune profile may contribute to predispose HbAS children to a relative protection from malaria.