Histological, functional and transcriptomic alterations in the juvenile hippocampus in a mouse model of thyroid hormone resistance.

Yingxin FangPingping DangYue LiangDefa ZhaoRanran WangYue XiDan ZhangWei WangZhongyan ShanWeiping Teng Xiaochun Teng

Published in: European thyroid journal (2022)

The ThraE403X mutation results in histological and functional abnormalities, as well as transcriptomic alterations in the juvenile mouse hippocampus. This study of the ThraE403X mutant offers new insights into the biological cause of RTHα-associated neurological diseases.

Keyphrases

mouse model
single cell
cerebral ischemia
rna seq
cognitive impairment