Genetic and non-genetic predictors of risk for opioid dependence.
Peter J NaJoseph D DeakHenry R KranzlerRobert H PietrzakJoshua C GrayPublished in: Psychological medicine (2024)
Results suggest an interplay between genetics and psychosocial environment in contributing to OD risk. While PRS alone do not yet have useful clinical predictive utility, psychosocial factors may help enhance prediction. These findings could inform more targeted clinical and policy interventions to help address this public health crisis.