Integrating Neuroprotective and Anti-inflammatory Strategies in the Development of PI3K Inhibitors for Enhanced Cancer Therapy.

The inhibition of phosphoinositide 3-kinases (PI3Ks) is a promising approach in cancer therapy due to their critical role in cellular growth, proliferation, and survival. This Patent Highlight explores the mechanism of action of novel PI3K inhibitors, emphasizing their efficacy in targeting various PI3K isoforms. The work integrates neuroprotective and anti-inflammatory strategies from related patents, highlighting their potential to enhance the therapeutic profile of these inhibitors. It also considers advanced diagnostic methods for monitoring treatment efficacy and safety, underscoring the need for a comprehensive approach to cancer treatment.