Login / Signup

A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells.

Tianming ZhaoQiang HeShurong XieHuien ZhanCheng JiangShengbin LinFangshu LiuCong WangGuo ChenHui Zeng
Published in: Molecular medicine (Cambridge, Mass.) (2023)
This study identified a novel and selective Mcl-1 inhibitor MI-238 and demonstrated that the development of MI-238 provides a novel strategy to improve the outcome of venetoclax therapy in AML.
Keyphrases
  • chronic lymphocytic leukemia
  • oxidative stress
  • acute myeloid leukemia
  • endoplasmic reticulum stress
  • cell death
  • cell cycle arrest
  • replacement therapy