Safety and Stability of Antibody-Dye Conjugate in Optical Molecular Imaging.

Jacqueline PeiGeorgina JuniperNynke S van den BergNaoki NishoTrevor BroadtAnthony R WelchGrace S YiRoan C RaymundoStefania U ChiritaGuolan LuGiri KrishnanYu-Jin LeeShrey KapoorQuan ZhouA Dimitrios ColevasNatalie S LuiGeorge A PoultsidesGordon LiKurt R ZinnEben L Rosenthal

Published in: Molecular imaging and biology (2020)

Panitumumab-IRDye800CW was safe and stable to administer over a 54-month window with a low rate of adverse events (7.4 %) which is consistent with the rate associated with panitumumab alone. This data supports re-purposing therapeutic antibodies as diagnostic imaging agents with limited preclinical toxicology studies.

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