Endothelial progenitors increase vascularization and improve fibroblasts function that prevent medication-related osteonecrosis of the jaw.

Ofri DoppeltGal CohenTal TamariRina ElimelechNadin SabbahHadar Zigdon Giladi

Published in: Oral diseases (2020)

EPC rescued fibroblasts from the cytotoxic effect of ZOL/DEX and elevated serum VEGF and vessel density that might reduce MRONJ occurrence to 20% compared to 50% in a similar model.

Keyphrases

endothelial cells
extracellular matrix
risk assessment
vascular endothelial growth factor
healthcare
adverse drug
tissue engineering
drug induced