CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses.

Camilla BoveSilvia ArcangeliLaura FalconeBarbara CamisaRita El KhouryBeatrice GrecoAnna De LuciaAlice BergaminiAttilio BondanzaFabio CiceriChiara BoniniMonica Casucci

Published in: Journal for immunotherapy of cancer (2023)

Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.

Keyphrases

induced apoptosis
nk cells
electronic health record
machine learning
cell cycle arrest
drug delivery
risk assessment
case report
big data
signaling pathway
bone marrow
climate change
deep learning