Changing behind the scenes.

Published in: The Journal of experimental medicine (2024)

Th17 cell plasticity is associated with pathogenicity in chronic inflammation. In a model of periodontitis, McClure et al. (https://doi.org/10.1084/jem.20232015) describe location-dependent divergence in Th17 plasticity, with surprisingly limited conversion in inflamed gingiva but emergence of protective exTh17-TfH cells in draining LN that enhance protective antibody.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
single cell
cell therapy
endoplasmic reticulum stress
signaling pathway
stem cells
escherichia coli
pseudomonas aeruginosa