Fisetin alleviates thioacetamide-induced hepatic fibrosis in rats by inhibiting Wnt/β-catenin signaling pathway.

Amany A El-FadalyNehal A AfifiWafaa El-ErakyAbeer SalamaMohamed F AbdelhameedSahar S Abd El-RahmanAmer Ramadan

Published in: Immunopharmacology and immunotoxicology (2022)

suppressing the Wnt/β-catenin pathway, modulating MMP-9 and TIMP-1, and inhibiting multiple profibrogenic factors, besides its antioxidant and anti-inflammatory effects. Therefore, fisetin is a promising therapeutic candidate for hepatic fibrosis.

Keyphrases

signaling pathway
liver fibrosis
cell proliferation
stem cells
high glucose
oxidative stress
diabetic rats
anti inflammatory
drug induced
endothelial cells