Pharmacokinetics of once-daily darunavir/ritonavir in second-line treatment in African children with HIV.
Lufina Tsirizani GalileyaShaghayegh Mohsenian NaghaniHylke WaalewijnAlexander J SzubertVeronica MulengaChishala ChabalaMutsa Bwakura-DangarembiziMoses ChitsamatangaDiana A RutebarikaVictor MusiimeMariam KasoziAbbas LugemwaLara N MonkiewiczHelen M McIlleronDavid M BurgerDiana M GibbPaolo DentiRoeland E WasmannAngela ColbersPublished in: The Journal of antimicrobial chemotherapy (2024)
Darunavir exposures achieved in our trial are within safe range. Darunavir/ritonavir can safely be co-administered with TAF/FTC. Both WHO-recommended 600/100 mg and CHAPAS-4 800/100 mg darunavir/ritonavir doses for the 25-34.9 kg weight band offer favourable exposures. The choice between them can depend on tablet availability.