Evidence of Placental Villous Inflammation and Apoptosis in Third-Trimester Symptomatic SARS-CoV-2 Maternal Infection.
Manggala Pasca WardhanaKuntaman KuntamanBudi UtomoRozi Aditya AryanandaSalsabila Nabilah RifdahIfan Ali WafaAlmira Aulia ShahnazDahlia NingrumNareswari Imanadha CinintaGrace ArianiJan M M van LithErry Gumilar DachlanPublished in: Yonsei medical journal (2024)
The presence of SARS-CoV-2 spike protein as well as altered inflammatory and apoptotic processes may indicate the presence of placental disturbance in third-trimester maternal COVID-19 infection. The lack of correlation between placental disruption and maternal severity status suggests the need for more research to understand the infection process and any potential long-term impacts on all offsprings born to COVID-19-infected pregnant women.
Keyphrases
- sars cov
- pregnancy outcomes
- pregnant women
- birth weight
- gestational age
- oxidative stress
- respiratory syndrome coronavirus
- cell death
- preterm birth
- coronavirus disease
- endoplasmic reticulum stress
- low birth weight
- cell cycle arrest
- risk assessment
- human health
- cell proliferation
- weight gain
- preterm infants
- small molecule
- protein protein
- binding protein