Biaryl sulfonamides as cisoid azosteres for photopharmacology.

Piermichele Kobauri Wiktor Szymanski Fangyuan Cao Sebastian Thallmair Siewert-Jan Marrink Martin D Witte Frank J Dekker Ben L Feringa

Published in: Chemical communications (Cambridge, England) (2021)

Biaryl sulfonamides are excellent candidates for the azologization approach that yields photoswitchable drugs more active in their metastable cis state, compared to the stable trans state. Here we present the scope and limitations of this strategy for rational design in photopharmacology.

Keyphrases

solid phase extraction
drug induced